反应详情

Ethyl 4-(3-(cyclopropylmethyl)ureido)benzoate (55.3 mmol, 14.5 g) was suspended in ethanol (400 ml) and 4M sodium hydroxide (332 mmol, 83 mL) added. The reaction was then refluxed until complete saponification was achieved. The ethanol was removed by evaporation and the reaction neutralised with concentrated hydrochloric acid. The white precipitate was collected and washed with water. The material was dried under vacuum to give the title compound (12.19 g)

1. temperatureThe reaction was then refluxed until complete saponification
2. customThe ethanol was removed by evaporation
3. customthe reaction neutralised with concentrated hydrochloric acid
4. customThe white precipitate was collected
5. washwashed with water
6. customThe material was dried under vacuum