Potassium Carbonate → Methyl 5-((4-(4-(3-(cyclopropylmethyl)ureido)benzoyl)piperazin-1-yl)methyl)thiophene-2-carboxylate

Participants

Reaction Steps

1-(Cyclopropylmethyl)-3-(4-(piperazine-1-carbonyl)phenyl)urea (4.25 mmol, 1.286 g), methyl 5-(bromomethyl)thiophene-2-carboxylate (4.25 mmol, 1 g) and potassium carbonate (12.76 mmol, 1.764 g) were stirred at room temperature in acetonitrile (20 mL) for 18 hours. The reaction mixture was concentrated at reduced pressure and the resulting residue taken up in dichloromethane, washed with water, dried over sodium sulfate and concentrated under vacuum to afford the title compound (1.764 g). MS (ESI) m/z 457.5 [M+H]+

Provenance & Evidence