tert-Butyl isocyanate → HCID 58055788, compound

HRID 408868Notes

Reaction equation

HRID 408868 reaction equation
[C:1]([N:5]=[C:6]=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:8][C:9]1[CH:13]=[CH:12][NH:11][N:10]=1>ClCCl>[C:1]([NH:5][C:6]([N:11]1[CH:12]=[CH:13][C:9]([CH3:8])=[N:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 62412tert-Butyl isocyanateHCID 178428694HCID 178428694, compound

Product 1

HCID 58055788HCID 58055788, compoundYield 95.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To tert-butyl isocyanate (1.57 mL, 1.34 g, 13.70 mmol) in dichloromethane (30 mL) was added 3-methyl-1H-pyrazole (0.98 mL, 1 g, 12.18 mmol). The mixture was stirred overnight at room temperature and then concentrated under vacuum. The crude material was purified by silica chromatography (eluting with dichloromethane) to give the title compound (2.1 g).

Workup

  1. concentrationconcentrated under vacuum
  2. customThe crude material was purified by silica chromatography (eluting with dichloromethane)

Sources & evidence

ORD record
ord-6eede4765d61477786352c79589dc72b
Source dataset
uspto-grants-2014_06
Patent number
US08759352B2

Reaction notes

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