HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Sodium 6-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)picolinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 58055793 | HCID 58055793 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Sodium 6-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)picolinate | HCID 66661327 | 79.4% |
Reaction Steps
Methyl 6-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)picolinate (400 mg, 0.852 mmol) and sodium hydroxide (35 mg, 0.852 mmol) were combined and heated to reflux for 18 hours in methanol. The reaction mixture was concentrated at reduced pressure to afford the title compound (323 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759352B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-7b60709f6fe248068aaa42dc7c002603 |
| Source note | uspto-grants-2014_06 |