反应详情

Using the general procedure for synthesizing naphthyl (amino acid ester) phosphorochloridates the tosylate salt of (S)-tetrahydro-2H-pyran-4-yl 2-aminopropanoate (1.00 g, 2.90 mmol), naphthalen-1-yl phosphorodichloridate (0.76 g, 2.90 mmol) and TEA (0.80 mL, 5.79 mmol) in 30 mL of dry DCM, were combined to give (2S)-tetrahydro-2H-pyran-4-yl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)propanoate in 70% yield (0.84 g), as a clear, yellow, thick oil.