Dichloromethane → HCID 66779058, compound

Participants

Reaction Steps

Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates, the tosylate salt of (S)-((S)-1-phenylethyl) 2-amino-3-methylbutanoate (2 g), naphthalen-1-yl phosphorodichloridate (1.33 g), TEA (1.41 mL) and DCM (60 mL) were combined to give (2S)-((S)-1-phenylethyl)-2-(chloro(naphthalen-1-yloxy)phosphorylamino)-3-methylbutanoate in an 96% yield (2.17 g) as a pale yellow thick oil.

Provenance & Evidence