Dichloromethane → HCID 66779102, compound

Participants

Reaction Steps

Using the general procedure for synthesizing naphthyl (amino acid ester) phosphorochloridates the hydrochloride salt of L-valine methyl ester (2.00 g, 11.93 mmol), naphthalen-1-yl phosphorodichloridate (0.77 g, 11.93 mmol) and TEA (4.11 mL, 23.85 mmol) in 20 mL of dry DCM, were combined to give (2S)-methyl 2-(chloro(naphthalen-1-yloxy)-phosphorylamino)-3-methylbutanoate in 62% yield (2.63 g), as a clear, yellow, thick oil.

Provenance & Evidence