Dichloromethane → HCID 66779267, compound

Participants

Reaction Steps

Using the general procedure for synthesizing naphthyl (amino acid ester) phosphorochloridates and tosylate salt of (S)-cyclopentyl-2-amino-3-methylbutanoate (2.58 g, 7.2 mmol), naphthalene-1-yl phosphorodichloridate (1.88 g, 7.2 mmol), triethyl amine (2.014 mL, 14.4 mmol) and dichloromethane (20 mL) were combined to give 2.12 g of desired (2S)-cyclopentyl 2-(chloro(naphthalen-1-yloxy)-phosphorylamino)-3-methylbutanoate as a pale yellow viscous oil in 72% yield.

Provenance & Evidence