Naphthalene → HCID 66778987, compound

Participants

Reaction Steps

Using the general procedure for synthesizing naphthalene (amino acid ester) phosphorochloridates, the hydrochloride salt of cyclohexyloxy-L-valine (1.8 g), was combined with naphthalene-1-yl phosphorodichloridate (1.99 g), TEA (2.12 mL), and DCM (25 mL) to give (2S)-cyclohexyl 2-(chloro(naphthalen-1-yloxy)-phosphorylamino)-3-methylbutanoate in a 72% yield (2.34 g) as a pale yellow thick oil:

Provenance & Evidence