Dichloromethane → HCID 66779478, compound

Participants

Reaction Steps

Using the general procedure for synthesizing naphthylalene (amino acid ester) phosphorochloridates and tosylate salt of (S)-tetrahydro-2H-pyran-4-yl-2-amino-3-methylbutanoate (3.76 g, 10.0 mmol), naphthalene-1-yl phosphorodichloridate (2.62 g, 10.0 mmol), triethylamine (2.81 mL, 2.0 mmol) and dichloromethane (54 mL) were combined to give 2.89 g of desired (2S)-tetrahydro-2H-pyran-4-yl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-3-methylbutanoate as a pale yellow viscous oil in 67% yield.

Provenance & Evidence