HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 86662570, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | p-Toluenesulfonate | HCID 85570 | — |
| Reactant | HCID 86662556 | HCID 86662556 | — |
| Reactant | HCID 86662571 | HCID 86662571 | — |
| Product | HCID 86662570 | HCID 86662570 | — |
Reaction Steps
Using the general procedure for synthesizing naphthyl (amino acid ester) phosphorochloridates the tosylate salt of (S)-neopentyl 2-amino-3-methylbutanoate (776 mg), and (S)-methyl 2-(6-(dichlorophosphoryloxy)naphthalen-2-yl)propanoate (750 mg), TEA (0.6 mL) and DCM (15 mL) were combined to give 580 mg of desired (2S)-neopentyl 2-(chloro(6-((S)-1-methoxy-1-oxopropan-2-yl)naphthalen-2-yloxy)phosphorylamino)-3-methylbutanoate as gummy solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759318B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-208f16021d384d59b20c5f7ec40102d9 |
| Source note | uspto-grants-2014_06 |