Dichloromethane → HCID 86662572, compound

Participants

Reaction Steps

Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates the tosylate salt of (S)-2,4-difluorobenzyl 2-amino-3-methylbutanoate (1.7 g, 4.1 mmol), quinoline 6-yloxy phosphorodichloridate (1.08 g, 4.1 mmol), triethyl amine (1.15 mL, 8.2 mmol) and dichloromethane (30 mL) were combined to give 462 mg of desired (2S)-2,4-difluorobenzyl 2-(chloro(quinolin-6-yloxy)phosphorylamino)-3-methylbutanoate after short silica gel chromatography as pale yellow gummy syrup in 24% yield.

Provenance & Evidence