HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 86662574, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | p-Toluenesulfonate | HCID 85570 | — |
| Reactant | HCID 86662558 | HCID 86662558 | — |
| Reactant | HCID 86662571 | HCID 86662571 | — |
| Product | HCID 86662574 | HCID 86662574 | — |
Reaction Steps
Using the general procedure for synthesizing naphthyl (amino acid ester) phosphorochloridates the tosylate salt of (S)-neopentyl-2-amino-3-methylbutanoate (1.9 g), quinolin-6-yl phosphorodichloridate (1.4 g), TEA (1.49 mL) and DCM (20 mL) were combined to give 600 mg of desired (2S)-neopentyl 2-(chloro(quinolin-6-yloxy)phosphorylamino)-3-methylbutanoate as thick oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759318B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-73921d3d8ae041fe96313722ffe80521 |
| Source note | uspto-grants-2014_06 |