Dichloromethane → HCID 86662575, compound

Participants

Reaction Steps

Using the general procedure for synthesizing naphthyl (amino acid ester) phosphorochloridates, the tosylate salt of neopentyl-2-amino-3-methylbutanoate (1.2 g, 3.4 mmol), quinoline 8-yloxy phosphorodichloridate (900 mg, 3.4 mmol), triethyl amine (0.96 mL, 6.9 mmol) and dichloromethane (30 mL) were combined to give 3.1 g crude desired (2S)-neopentyl 2-(chloro(quinolin-8-yloxy)phosphorylamino)-3-methylbutanoate which was used directly to next step.

Provenance & Evidence