HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 86662578, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | p-Toluenesulfonate | HCID 85570 | — |
| Reactant | 1-Dichlorophosphoryloxynaphthalene | HCID 575631 | — |
| Reactant | HCID 86662579 | HCID 86662579 | — |
| Product | HCID 86662578 | HCID 86662578 | — |
Reaction Steps
Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates the tosylate salt of (R)-neopentyl 2-aminopropanoate (3 g), naphthalene-1-yl phosphorodichloridate (2.36 g), TEA (2.52 mL) and DCM (90 mL) were combined to give (2R)-neopentyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)propanoate as a crude pale yellow thick oil. The crude compound was taken forward without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759318B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-62943deac8c64852beffbaf2d4e4c1fa |
| Source note | uspto-grants-2014_06 |