Dichloromethane → HCID 66779010, compound

Participants

Reaction Steps

Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates the tosylate salt of (S)-((S)-1-phenylethyl) 2-amino-4-(methylthio)butanoate (2.00 g, 4.70 mmol), naphthalene-1-yl phosphorodichloridate (1.23 g, 4.70 mmol) and TEA (1.31 mL, 9.40 mmol) in 30 mL of dry DCM, were combined to give (2S)-((S)-1-phenylethyl) 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-4-(methylthio)butanoate in 74% yield (1.67 g), as a clear, yellow, thick oil.

Provenance & Evidence