Dichloromethane → HCID 86662580, compound

Participants

Reaction Steps

Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates the tosylate salt of (S)-neopentyl 2-amino-4-(methylthio)butanoate (2.00 g, 5.11 mmol), naphthalene-1-yl phosphorodichloridate (1.30 g, 5.11 mmol) and TEA (1.42 mL, 10.22 mmol) in 30 mL of dry DCM, were combined to give (2S)-neopentyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-4-(methylthio)butanoate in 41% yield (0.92 g), as a clear, yellow, thick oil.

Provenance & Evidence