Dichloromethane → HCID 86662582, compound

Participants

Reaction Steps

Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates the tosylate salt of (S)-neopentyl 2-amino-4-methylpentanoate (2.33 g), naphthalen-1-yl phosphorodichloridate (1.63 g), TEA (1.74 mL) and DCM (70 mL) were combined to give (2S)-neopentyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-4-methylpentanoate in an 77% yield (2.04 g), as a pale yellow thick oil.

Provenance & Evidence