Dichloromethane → HCID 86662584, compound

Participants

Reaction Steps

Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates the tosylate salt of (2S,3R)-neopentyl 2-amino-3-methylpentanoate (2.5 g), naphthalen-1-yl phosphorodichloridate (1.75 g), TEA (1.86 mL) and DCM (50 mL) were combined to give (2S,3R)-neopentyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-3-methylpentanoate in a 37% yield (1.06 g) as a pale yellow thick oil.

Provenance & Evidence