Hydrochloric Acid → HCID 86662587, compound

Participants

Reaction Steps

Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates, the HCl salt of (S)-propyl 2-amino-2-phenylacetate (1 g), naphthalen-1-yl phosphorodichloridate (1.14 g), TEA (1.21 mL) and DCM (30 mL) were combined to give (2S)-propyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate in an 83% yield (1.51 g) as a pale yellow thick oil.

Provenance & Evidence