反应详情

Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates the tosylate salt of (R)-benzyl 2-amino-2-phenylacetate (1.50 g, 3.63 mmol), and naphthalen-1-yl phosphorodichloridate (0.95 g, 3.63 mmol) and TEA (1.01 mL, 7.26 mmol) in 20 mL of dry DCM, were combined to give (2R)-benzyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate in 72% yield (1.21 g), as a clear, yellow, thick oil.