Dichloromethane → HCID 86662589, compound

Participants

Reaction Steps

Using the general procedure for synthesizing naphthyl (amino acid ester) phosphorochloridates the hydrochloride salt of (R)-propyl 2-amino-2-phenylacetate (2.00 g, 8.71 mmol), naphthalen-1-yl phosphorodichloridate (2.27, 8.71 mmol) and TEA (2.42 mL, 17.41 mmol) were combined in 20 mL of dry DCM, to give (2R)-propyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate in 59% yield (2.15 g), as a clear, yellow, thick oil.

Provenance & Evidence