Dichloromethane → (2R)-neopentyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate

Participants

Reaction Steps

Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates the tosylate salt of (R)-neopentyl 2-amino-2-phenylacetate (0.81 g, 2.08 mmol), naphthalen-1-yloxy phosphorodichloridate (0.54 g, 2.08 mmol), triethylamine (0.58 mL, 4.16 mmol) and dichloromethane (10 mL) were combined to give 0.51 g of desired (2R)-neopentyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate in 58% yield as pale yellow thick oil.

Provenance & Evidence