反应详情

Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates the hydrochloride salt of (R)-cyclohexyl 2-amino-2-phenylacetate (2.00 g, 7.41 mmol), naphthalen-1-yl phosphorodichloridate (1.94 g, 7.41 mmol) and TEA (2.06 mL, 14.83 mmol) were combined in 15 mL of dry DCM, to give (2R)-cyclohexyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate in 60% yield (2.75 g), as a clear, yellow, thick oil.