Ethyl Acetate → HCID 77230810, compound

Participants

Reaction Conditions

Reaction Steps

A 2.2 g (7.5 mmol) portion of 1-(2-bromo-6-chlorothieno[2,3-b]pyridin-5-yl)-ethanol was dissolved in toluene and treated with manganese dioxide (6.5 g, 75 mmol, 10 eq). The mixture was heated to 90° C. overnight, then cooled rt and filtered through Celite™. The filter cake was rinsed with toluene and concentrated to afford crude material. The residue was purifed by column chromatography using ethyl acetate in hexanes to afford 1-(2-bromo-6-chlorothieno[2,3-b]pyridin-5-yl)ethanone. LC/MS (M+1, found=291.9). 1H NMR (400 MHz, CDCl3) δ 8.17 (s, 1H), 7.36 (s, 1H), 2.75 (s, 3H) ppm.

Provenance & Evidence