HCID 77230809, compound → HCID 77230808, compound

Participants

Reaction Steps

To a solution of 1-(2,6-dichlorothieno[2,3-b]pyridin-5-yl)ethanol (5 g, 20.15 mmol) in 200 ml, of anhydrous toluene was added MnO2 (14 g, 161 mmol). The reaction was heated to reflux overnight, cooled to rt, filtered through Celite™ and rinsed with ethyl acetate. Concentration and purification by column chromatography afforded 1-(2,6-dichlorothieno[2,3-b]pyridin-5-yl)ethanone. 1H NMR (400 MHz, CDCl3) δ 8.15 (s, 1H), 7.19 (s, 1H), 2.75 (s, 3H) ppm.

Provenance & Evidence