Dichloromethane → (R)-2-(3-(4-amino-3-(4-(3,5-difluorophenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-3-cyclopropylacrylonitrile

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Reaction Steps

Into a 50 mL round-bottom flask, was placed a solution of 3-[(3R)-3-[4-amino-3-[4-(3,5-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-oxopropanenitrile (150 mg, 0.31 mmol, 1.00 equiv) in methanol (20 mL), cyclopropanecarbaldehyde (64 mg, 0.91 mmol, 3.00 equiv), piperidine (13 mg, 0.15 mmol, 0.50 equiv), and dichloromethane (5 mL). The resulting solution was stirred for 12 h at room temperature and then concentrated under vacuum. The residue was loaded onto a silica gel column and eluted with dichloromethane/methanol (100:1) to give 70 mg (42%) of the title compound as a white solid. LC-MS: (ES, m/z): 542 [M+H]+. 1HNMR (300 MHz, CDCl3, ppm) 8.405 (1H, s), 7.762˜7.715 (2H, m), 7.282˜7.223 (2H, m), 6.656˜6.575 (4H, m), 6.696 (2H, s), 5.022˜4.924 (1H, m), 4.8-2.9 (4H, m), 2.424˜2.301 (2H, m), 2.271˜2.259 (3H, d), 1.295˜1.228 (2H, t), 0.903˜0.892 (2H, d).

Provenance & Evidence