Glycine → HCID 16734924, compound

HRID 409223Notes

Reaction equation

C(O[C:6]([C:8]1[N:9]=[C:10]([C:28]#[N:29])[C:11]2[C:16]([C:17]=1[OH:18])=[CH:15][C:14]([O:19][C:20]1[C:25]([CH3:26])=[CH:24][CH:23]=[CH:22][C:21]=1[CH3:27])=[CH:13][CH:12]=2)=[O:7])CCC.[NH2:30][CH2:31][C:32]([OH:34])=[O:33]>>[C:28]([C:10]1[C:11]2[C:16](=[CH:15][C:14]([O:19][C:20]3[C:21]([CH3:27])=[CH:22][CH:23]=[CH:24][C:25]=3[CH3:26])=[CH:13][CH:12]=2)[C:6]([OH:7])=[C:8]([C:17]([NH:30][CH2:31][C:32]([OH:34])=[O:33])=[O:18])[N:9]=1)#[N:29]

Participants

Reactant 2

HCID 750Glycine

HCID 67110152HCID 67110152, compound

Product 1

HCID 16734924HCID 16734924, compound

Procedure

The title compound was synthesized from 1-Cyano-6-(2,6-dimethyl-phenoxy)-4-hydroxy-isoquinoline-3-carboxylic acid butyl ester and glycine in analogy to example 1b; MS-(−)-ion: M−1=390.0.

Sources & evidence

ORD record: ord-cc8a7e5e05f948d98d118ae9201d2a7d
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08759373B2

Reaction notes

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