p-Acetanisidide, alpha,alpha,alpha-trifluoro- → HCID 86689275, compound

Participants

Reaction Steps

N-(4-(trifluoromethoxy)phenyl)acetamide (112 g, 0.511 mol) was dissolved in THF (400 ml) and Lawesson's Reagent (2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide) (100 g, 0.247 mol) was added. The suspension was stirred at rt for 3 days, then filtered, filtrate evaporated and the residue was purified by chromatography (20% EtOAc in hexane) to give 100.5 g (84%) of N-(4-(trifluoromethoxy)phenyl)ethanethioamide.

Provenance & Evidence