N-bromobutanimide → HCID 68277893, compound

Participants

Reaction Steps

A mixture of 2-methyl-6-(trifluoromethoxy)benzo[d]thiazole (9 g, 0.0386 mol) and NBS (6.9 g, 0.0386 mol) and benzoyl peroxide (0.25 g) in CCl4 (250 ml) was heated to reflux under lamp light (150 Watt) for 4 hr. Then the mixture was filtered, evaporated and purified using the Combi-Flash instrument to give 4.3 g (28.5%) of di-bromo product, 3.1 g (34%) of starting material and 4.6 g (38.2%) of 2-(bromomethyl)-6-(trifluoromethoxy)benzo[d]thiazole.

Provenance & Evidence