Beta-Alanine → HCID 86636691, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 2-(5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid (0.031 g, 0.117 mmol) and 5-(4-trifluoromethoxy-phenyl)thiophene-2-carbaldehyde (0.030 g, 0.117 mmol) in acetic acid 5 mL is added β-alanine (1.042 mg, 0.012 mmol) and heat to 170° C. for 30 min under microwave irradiation. The resulting reaction mixture is cooled down and the solvent is removed. The pure product (0.035 g, 0.069 mmol, red solid) is obtained by column chromatography using MeOH/DCM, 2-7% ration solvent system. 1H-NMR (CD3OD/300 MHz): 7.91 (m, 2H), 7.32 (d, J=9.0 Hz, 2H), 7.14 (m, 5H), 7.02 (m, 2H), 6.47 (s, 1H), 5.64 (dd, J=11.1, 5.4 Hz, 11H), 3.70 (dd, J=14.1, 12.6 Hz, 1H), 3.53 (dd, J=14.1, 5.1 Hz, 1H). MS (ES−, m/z): 501.4 (M−, 100.0).

Provenance & Evidence