HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-amino-N-(isoquinolin-6-yl)-3-(thiophen-3-yl)propanamide dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-1-(thiophen-3-yl)propylcarbamate | HCID 59161737 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-amino-N-(isoquinolin-6-yl)-3-(thiophen-3-yl)propanamide dihydrochloride | HCID 66905764 | — |
Reaction Steps
To tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-1-(thiophen-3-yl)propylcarbamate (E5) in CH2Cl2 was added HCl (4N in dioxane), and the solution was stirred for 8 hours. The solvents were evaporated to give 3-amino-N-(isoquinolin-6-yl)-3-(thiophen-3-yl)propanamide dihydrochloride (E6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759388B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-4c20b38421a54cb2bdf4175bbba2de20 |
| Source note | uspto-grants-2014_06 |