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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 409408Generated: October 27, 2026

Acetic Acid → 3-(Dimethylamino)-2-(thiophen-3-yl)propanoic acid

https://huagongshe.com/reaction/409408

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
ReactantWaterHCID 962—
ReactantLithium HydroxideHCID 3939—
ReactantMethyl 3-(dimethylamino)-2-(thiophen-3-yl)propanoateHCID 59161743—
SolventMethanol tetrahydrofuran waterHCID 21892291—
Product3-(Dimethylamino)-2-(thiophen-3-yl)propanoic acidHCID 59161746—

Reaction Steps

To methyl 3-(dimethylamino)-2-(thiophen-3-yl)propanoate (E42) in THF/H2O/MeOH was added LiOH*H2O, and the solution was stirred for 12 hours. AcOH was added and the solvents were evaporated. Column chromatography (SiO2, 10-15% 2M NH3— MeOH/EtOH) gave pure 3-(dimethylamino)-2-(thiophen-3-yl)propanoic acid (E43).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08759388B2
Source datasetuspto-grants-2014_06
ORD IDord-01a870b456d644579491227f767645d6
Source noteuspto-grants-2014_06