Hydrochloric Acid → HCID 59614389, compound

Participants

Reaction Steps

To a mixture of 1-[4-((2R,4S)-4-{(3,5-bis-trifluoromethyl-benzyl)-[5-(3-methyl-2-oxo-imidazolidin-1-yl)-pyrimidin-2-yl]-amino}-2-ethyl-pyrrolidin-1-yl)-5-chloro-pyrimidin-2-yl]-piperidine-4-carboxylic acid ethyl ester (70 mg, 0.09 mmol) in EtOH (1 mL) is added 1N NaOH (0.45 mL, 0.45 mmol). The reaction mixture is stirred at room temperature for 1 hour. After quench with 1N HCl (0.45 mL, 0.45 mmol), the mixture is washed with brine and extracted with EtOAc. The combined organic layer is dried over MgSO4 then concentrated under reduced pressure to give 1-[4-((2R,4S)-4-{(3,5-bis-trifluoromethyl-benzyl)-[5-(3-methyl-2-oxo-imidazolidin-1-yl)-pyrimidin-2-yl]-amino}-2-ethyl-pyrrolidin-1-yl)-5-chloro-pyrimidin-2-yl]-piperidine-4-carboxylic acid (66 mg, 97%).

Provenance & Evidence