Ammonium Chloride → HCID 86648395, compound

Participants

Reaction Steps

To a mixture of 2-((2R,4S)-4-{(3,5-bis-trifluoromethyl-benzyl)-[5-(1-methyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amino}-2-ethyl-pyrrolidin-1-yl)-5-trifluoromethyl-benzaldehyde (120 mg, 0.17 mmol) in THF (3 mL) is added MeMgBr (0.24 mL, 0.23 mmol) in THF solution (0.97M). The reaction mixture is stirred at room temperature for 0.5 hour. After addition of saturated NH4Cl aq., the mixture is extracted with EtOAc. The combined organic layer is dried over MgSO4 then concentrated under reduced pressure to give 1-[2-((2R,4S)-4-{(3,5-bis-trifluoromethyl-benzyl)-[5-(1-methyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amino}-2-ethyl-pyrrolidin-1-yl)-5-trifluoromethyl-phenyl]-ethanol as a colorless oil (122 mg, quant.). ESI-MS m/z: 687 [M+1]+, Retention time 2.05 min (condition A).

Provenance & Evidence