反应详情

温度

105 °C

A mixture of dihydro-3,3-dimethyl-2(3H)-furanone (10 mmol; 1.14 g), aqueous 1 M KOH solution (10 mmol) and one drop of phenolphthalein indicator (0.5% w/v in EtOH/water (1:1)) is stirred at 105° C. for 3.5 hours. The mixture is cooled to ambient temperature and concentration under reduced pressure. To the residue is added 10 mL of EtOH. To the solution is added 50 ml of Et2O, and the solid isolated by filtration and dried under 100 mbar at 50° C. to give potassium 4-hydroxy-2,2-dimethylbutyrate (1.21 g, 71%).

1. temperatureThe mixture is cooled to ambient temperature
2. concentrationconcentration under reduced pressure
3. additionTo the residue is added 10 mL of EtOH
4. additionTo the solution is added 50 ml of Et2O
5. customthe solid isolated by filtration
6. customdried under 100 mbar at 50° C.