huagongshe.com
HRID409481

反应详情

EQUATION

反应方程式

HRID 409481 的结构方程式

REACTANTS

反应物

1
结构：COC(=O)[C@H]1C[C@H](OCc2ccccc2)C1
HCID178501330

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@H]1C[C@H](O)C1
HCID178501328

未命名化合物

收率 94.5%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CO
溶剂HCID887

Methanol

CH4O

CONDITIONS

反应条件

温度
40 °C

PROCEDURE

实验过程

A solution of trans-3-benzyloxy-cyclobutanecarboxylic acid methyl ester (680 mg, 3.09 mmol) as 0.05 M solution in MeOH is pumped through the H-Cube™ flow hydrogenator fitted with a 10 mol % Pd/C catalyst cartridge heated to 40° C. at 10 bar. The flow rate is set at 1 ml/min. The solvent is removed under reduced pressure to give trans-3-hydroxy-cyclobutanecarboxylic acid methyl ester (380 mg, 94.5%); TLC (hexane/EtOAc, 1:1) Rf 0.38.

WORKUP

后处理

  1. customThe solvent is removed under reduced pressure