HCID 178501330, compound → HCID 178501328, compound

Participants

Reaction Conditions

Reaction Steps

A solution of trans-3-benzyloxy-cyclobutanecarboxylic acid methyl ester (730 mg, 3.32 mmol) as a 0.05 M solution in MeOH is pumped through the H-Cube™ flow hydrogenator fitted with a 10 mol % Pd/C catalyst cartridge heated to 40° C. at 10 bar. The flow rate was set at 1 ml/min. The solvent is removed under reduced pressure to give trans 3-hydroxy-cyclobutanecarboxylic acid methyl ester (400 mg, 92.7%); TLC (hexane/AcOEt, 1:1) Rf 0.38.

Provenance & Evidence