反应详情

To a solution of trans-4-aminomethyl-1-cyclohexanecarboxylic acid (10 mmol, 1.57 g) in methanol (10 mL) is added of thionyl chloride (12 mmol, 0.88 mL) at 0° C. The mixture is stirred at room temperature for 24 hours and then concentrated under reduced pressure. The residue is washed with hexane to obtain 1.9 g (92%) of trans-4-(aminomethyl)cyclohexanecarboxylic acid methyl ester hydrochloride as white solid. ESI-MS m/z: 172 [M+1]+, Retention time 2.12 min (condition B).

1. concentrationconcentrated under reduced pressure
2. washThe residue is washed with hexane