反应详情

To a solution of trans-4-aminocyclohexanecarboxylic acid (20 mmol, 2.86 g) in methanol (20 mL) is added thionyl chloride (24 mmol, 1.76 mL) at 0° C. The mixture is stirred at room temperature for 12 hours then concentrated under reduced pressure. The residue is washed with hexane to obtain 3.5 g (90%) of trans-4-aminocyclohexanecarboxylic acid methyl ester hydrochloride as white solid. ESI-MS m/z: 157 [M+1]+, Retention time 0.77 min (condition B).

1. concentrationthen concentrated under reduced pressure
2. washThe residue is washed with hexane