Acetic Anhydride → HCID 66653482, compound

HRID 409551Notes

Reaction equation

HRID 409551 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]([C:13]2[N:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]3=[C:15]([Br:22])[N:14]=2)=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[C:23]([NH:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]([C:13]2[N:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]3=[C:15]([Br:22])[N:14]=2)=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])(=[O:25])[CH3:24]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 66653348HCID 66653348, compound

Product 1

HCID 66653482HCID 66653482, compound

Procedure

0.92 g (2.56 mmol) of 2-amino-5-(1-bromoimidazo[1,5-a]pyridin-3-ylcarbonyl)benzoic acid in 30 ml of acetic anhydride are refluxed for 5.5 hours. The reaction medium is concentrated under reduced pressure. The residue is taken up in water and then filtered and dried under reduced pressure overnight at 40° C. 1.1 g of a yellow solid are obtained.

Workup

  1. concentrationThe reaction medium is concentrated under reduced pressure
  2. filtrationfiltered
  3. customdried under reduced pressure overnight at 40° C

Sources & evidence

ORD record
ord-b123b7f2c15b4d89997a8e82b1a2cb6d
Source dataset
uspto-grants-2014_06
Patent number
US08759344B2

Reaction notes

Loading…