HuagongsheHuagongshe Chemistry Print Report · For research reference only
Calcium Acetate → Rosuvastatin calcium
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Calcium Acetate | HCID 6116 | — |
| Reactant | Calcium Chloride | HCID 5284359 | — |
| Reactant | Calcium | HCID 5460341 | — |
| Reactant | Calcium Hydroxide | HCID 6093208 | — |
| Reactant | HCID 24758243 | HCID 24758243 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Rosuvastatin calcium | HCID 5282455 | — |
Reaction Steps
The rosuvastatin potassium salt obtained is further treated with mixture of toluene and ethyl acetate followed by treatment with suitable calcium source like calcium chloride, calcium acetate, calcium hydroxide and the like. In particular, calcium acetate is used to obtain rosuvastatin calcium salt. The isolated rosuvastatin calcium is in amorphous form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759518B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-4576a266c4144cb199ef921f97ed8560 |
| Source note | uspto-grants-2014_06 |