反应详情

Acetic anhydride (13 ml, 137 mmol, 1.05 equiv) is added (in 15 min) to a suspension of 3,5-dimethoxyaniline (20 g, 131 mmol) in toluene (110 mL), keeping the internal temperature in the range of 35-45° C. The reaction mixture is allowed to stir for 20 h at RT. The resulting thick, grey suspension is diluted with hexane (55 mL) and filtered. The residue in the filter is washed with toluene/Hex (2:1, 70 mL) and Hex, and dried to provide the title compound as a white solid. API-ES-MS: 196.1 [MH]+, tR=3.03 min (purity: 100%, system 1).

1. customin the range of 35-45° C
2. filtrationfiltered
3. washThe residue in the filter is washed with toluene/Hex (2:1, 70 mL) and Hex
4. customdried