HCID 23630232, compound → HCID 23630246, compound

Participants

Reaction Steps

A suspension of 1-[6-(4-benzyloxy-phenylamino)-pyrimidin-4-yl]-3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-methyl-urea (Example 5) (67 mg, 0.121 mmol), palladium on carbon (20 mg), and MeOH (3.5 mL) is stirred for 3 h at RT, under a hydrogen atmosphere. The reaction mixture is filtered through a pad of celite and concentrated. The residue is purified by silica gel column chromatography to provide the title compound as a brown solid: ESI-MS: 464.2/466.2 [MH]+; tR=3.91 min (purity: 100%, system 1).

Provenance & Evidence