1-[2-(2-Fluoro-4-nitrophenoxy)ethyl]pyrrolidine → 3-Fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)aniline

Participants

Reaction Steps

A suspension of 1-[2-(2-fluoro-4-nitro-phenoxy)-ethyl]-pyrrolidine (1.25 g, 4.92 mmol) and 10% palladium on carbon (0.2 g) in EtOH (20 mL) is stirred for 1 h at RT, under a hydrogen atmosphere. The reaction mixture is filtered through a pad of celite and concentrated to afford the title compound as a brown oil: ESI-MS: 225.1 [MH]+; tR=0.80 min (system 1).

Provenance & Evidence