HCID 2947839, compound → 4-(4-ETHYLPIPERAZIN-1-YL)-3-FLUOROANILINE

HRID 409682Notes

Reaction equation

HRID 409682 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][C:10]=2[F:18])[CH2:5][CH2:4]1)[CH3:2]>[Ni].CO>[CH2:1]([N:3]1[CH2:4][CH2:5][N:6]([C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][C:10]=2[F:18])[CH2:7][CH2:8]1)[CH3:2]

Participants

4

Reactant 1

HCID 2947839HCID 2947839, compound

Product 1

HCID 107515754-(4-ETHYLPIPERAZIN-1-YL)-3-FLUOROANILINE

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A suspension of 1-ethyl-4-(2-fluoro-4-nitro-phenyl)-piperazine (1.24 g, 15.1 mmol) and Raney Nickel (13 mg) in MeOH (6 mL) is stirred for 17 h at RT, under a hydrogen atmosphere. The reaction mixture is filtered through a pad of celite and concentrated to afford the title compound as a purple oil: ESI-MS: 224.1 [MH]+; tR=0.90 min (system 1).

Workup

  1. filtrationThe reaction mixture is filtered through a pad of celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-c0ed32ae19954df788eda612557ac838
Source dataset
uspto-grants-2014_06
Patent number
US08759517B2

Reaction notes

Loading…