Acetic Anhydride → HCID 69179379, compound

HRID 409686Notes

Reaction equation

HRID 409686 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH3:8][O:9][C:10]1[CH:11]=[C:12]([C:17]([F:20])([F:19])[F:18])[CH:13]=[C:14]([CH:16]=1)[NH2:15].CCCCCC>C1(C)C=CC=CC=1>[CH3:8][O:9][C:10]1[CH:11]=[C:12]([C:17]([F:18])([F:19])[F:20])[CH:13]=[C:14]([NH:15][C:1](=[O:3])[CH3:2])[CH:16]=1

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8058HexaneHCID 6056715-(Trifluoromethyl)-m-anisidine

Product 1

HCID 69179379HCID 69179379, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Acetic anhydride (1.22 ml, 12.8 mmol) is added during 10 min to a solution of 5-methoxy-3-trifluoromethyl-aniline (2.29 g, 12.0 mmol) in toluene (10 ml) at a temperature of 25-33° C. After 90 min at RT, hexane (10 ml) is added und the suspension is stirred for 20 min. Filtration, washing with toluene/hexane 2:1 and hexane gives the title compound: mp: 123-124° C.; API-MS: 234 [MH]+; TLC: Rf=0.27 (Hex/EtOAc, 1:1).

Workup

  1. filtrationFiltration
  2. washwashing with toluene/hexane 2:1 and hexane

Sources & evidence

ORD record
ord-57f5869cd2fa411aa70ca64bdd3af3f9
Source dataset
uspto-grants-2014_06
Patent number
US08759517B2

Reaction notes

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