HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxy-5-nitrobenzotrifluoride → 5-(Trifluoromethyl)-m-anisidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxy-5-nitrobenzotrifluoride | HCID 520597 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(Trifluoromethyl)-m-anisidine | HCID 605671 | — |
Reaction Steps
Hydrogenation of a solution of 3-methoxy-5-nitrobenzotrifluoride (6.19 g, 28 mmol) in MeOH (140 ml) in the presence of Pd—C (0.62 g, 10%), removal of the catalyst by filtration and concentration in vacuo of the resulting filtrate gives the title compound: API-MS: 190 [M-H]−; TLC: Rf=0.7 (EtOAc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759517B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-67abb34cc76940198df8bda9e21f5e13 |
| Source note | uspto-grants-2014_06 |