HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 409714Generated: October 30, 2026
4-Bromophenol → 1-Bromo-4-(cyclobutyloxy)benzene
https://huagongshe.com/reaction/409714
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Bromophenol | HCID 7808 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Bromocyclobutane | HCID 78110 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Bromo-4-(cyclobutyloxy)benzene | HCID 67987998 | — |
Reaction Steps
2.50 g (14.5 mmol) 4-bromophenol, 2.05 mL (21.7 mmol) cyclobutylbromide and 7.99 g (57.8 mmol) K2CO3 are dissolved in 25 mL DMF and stirred at 120° C. for 12 h. Afterwards the reaction mixture is diluted with water and extracted with EtOAc. The organic layer is dried over MgSO4 and the solvent is removed in vacuo. The crude product is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08759528B2 |
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| Source dataset | uspto-grants-2014_06 |
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| ORD ID | ord-86f47b0fec1549db966c451350fe63cd |
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| Source note | uspto-grants-2014_06 |
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