反应详情

温度

70 °C

To 3.30 g (9.50 mmol) 4-[4-(1-methoxycarbonyl-ethyl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester (VIII.1) in 20 mL MeOH are added 10.5 mL (10.5 mmol) 1N NaOH solution and the mixture is stirred at 70° C. for 1 h. After that time, the solvent is evaporated and the residue is washed with DCM. The residue is taken up in 1N HCl and the precipitate is filtered off and dried in vacuo to yield the desired product.

1. customAfter that time, the solvent is evaporated
2. washthe residue is washed with DCM
3. filtrationthe precipitate is filtered off
4. customdried in vacuo